One of the most common diseases in old age is dementia, also known as senile dementia because it usually begins after the age of 65. The wide-spread belief that Alzheimer’s and dementia are two different disorders is not true. Alzheimer’s is a form of dementia, as are, for example, vascular dementia (VAD) and Lewy body dementia.

Typically, the first signs of dementia are short-term memory loss and diminished retentive memory. Patients often gloss over this initial forgetfulness for months or even years, losing valuable time for treatment.

Other features of dementia are:

    – forgetfulness, confusion
    – irritability, aggressiveness
    – personality changes
    – depression
    – speech difficulties, loss of communication skills
    – disorientation in space and time.


These disorders are caused by a malfunction of the synapses (= connections) in the brain.
Due to this non-functioning cell communication, information cannot be stored and can no longer be processed due to the nerve cells being damaged.

A simple method for checking the brain performance of these patients is the Mini Mental State Examination (MMSE).

A person’s mind can be tested in less than 5 minutes, as follows.

    1. Patients are asked 10 orientation questions such as: “What day/month/year is today?”, “What is the date today?”, “In which city/country do we live?
    2. Recognition and memory can be checked by the patient having to describe 3 objects named by the examiner.
    3. Attention and concentration are tested by having the patient spell a 5-letter word backwards and repeat a sequence of numbers.
    4. The short-term memory is checked by the patient being asked to name the 3 objects from point 2 again.
    5. Understanding: this is tested by having the patient follow commands given by the examiner, such as: repeating words, making written requests, writing down accurate statements.

The maximum score is 30 points for healthy people; less than 24 points indicates reduced brain function. (You can read more about this in section 3.6. of Prof. George Birkmayer’s book “NADH, der biologische Wasserstoff, das Geheimnis unserer Lebensenergie”).

The question is: can dementia or other brain disorders be improved or even remedied entirely?

The answer is: YES, with NADH.

This has been demonstrated by a study at Georgetown University in Washington.

In this study, Alzheimer’s patients received 10 mg of NADH per day for 6 months. The brain performance of the patients was determined using standardised tests at the beginning and end of the 6 months. The results were impressive: the patients who received NADH showed significantly better brain performance than the patients who took placebo tablets. By contrast, brain performance deteriorated in the placebo patients.

Another study carried out by Professor DEMARIN at the University of Zagreb (1) confirmed the effect of NADH on a large number of Alzheimer’s patients (2). NADH not only stops the progression of dementia, it also improves patients’ cognitive performance. The effect of NADH most probably derives from a supply of energy by NADH.

Since the human brain consumes about one-third of the energy produced by the organism, ENERGY DEFICIENCY is the most plausible cause of brain disorders. This also explains why NADH, which increases ATP in every cell, has very positive effects on brain performance disorders, especially dementia. That is why NADH is also the best prevention for dementia. It also helps healthy people to stay physically and mentally fit.

1. Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G; Treatment of Alzheimer’s Disease with stabilized oral Nicotinamide Adenine Dinucleotide: A randomized, double-blind study;Drugs exptl. Clin.Res. 2004; 30: 327-337.

2. Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G, Martinic-Popovic,M. Puretic B., Birkmayer JGD; ENADA/NADH improves cognitive impairment of Alzheimer patients;J. Tumor Marker Oncology 2003; 18:43-49.