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Effects of NADH

Birkmayer, JG: NADH (coenzyme 1) – and its anti-ageing effects.

Nutrition Press – Fachzeitschrift für Mikronährstoffe, 9: 42-44 (2016). read article  

NADH-supplementation decreased pinacidil-primed I K(ATP) in ventricular cardiomyocytes by increasing intracellular ATP

Pelzmann B, Hallström S, Schaffer P, Lang P, Nadlinger K, Birkmayer GD, Vrecko C, Reibnegger G and Koidl B. Brit. J. Pharm. 2003 139, 749-754.  

The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) repairs DNA damage of PC12 cells induced by doxorubicin

Zhang JR, Vrecko K, Nadlinger K, Storga D, Birkmayer GD, Reibnegger G

J. Tumor Marker Oncol. 1998; 13, 5-17.

X-ray induced LO2 cells damage rescued by new antioxidant NADH

Fa-Quan L, Zhang JR.

World J. Gastorenterol. 2003, 9(8): 1781-1785.

The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) rescues PC 12 cells from Apoptosis

Zhang JR, Vrecko K, Nadlinger K. Storga D. Birkmayer GD, Reibnegger G

J. Tumor Marker Oncol. 1998; 13(3): 11-24.

The Cytoprotection of Nicotinamide Adenine Dinucleotide (NADH) by the Mitochondrial Regulation Mechanism

Meng Xu, Hang JR, Hui SSC

J. Tumor Marker Oncol. 1998; 17: 167 – 174.

The reduced coenzyme Nicotinamide Adenine Dinucleotide (NADH) prevent hepatic cells from Apoptosis

Meng Xu, Jiren Zhang

Int. Journal of Modern Cancer Therapy 2000: 3, 38 – 41.

The antioxidative capacity of ENADA®-NADH in humans

Reibnegger G, Greilberger J, Juergens G. and Oettl K.

J. Tumor Marker Oncol. 2003; 18, 37-41.

Oral NADH effects blood pressure, lipid peroxidation and lipid profile in spontaneously hypertensive rats

Busheri N, Taylor J, Lieberman S, Mirdamadi-Zonosi N, Birkmayer G, Preuss HG

Geriat. Nephrol. Urol. 1998; 18(2) 95-100.

NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaechromocytoma cells

Vrecko K, Storga D, Birkmayer GD, Möller R, Tarfeit E, Horejsi R, Reibnegger G

Biochimica et Biophysica Acta 1997; 1361: 59-65.

Effects of acute and chronic NADH Administration on Peripheral and Central Norepinenphrine and Dopamine Synthesis in the Rat

Gardier AM Birkmayer Institute for Parkinson Therapy, Internal Lab Report No. 94070401.

NADH: Sensor of blood flow in brain, muscle and other tissues

Ido Y., Chang K., Woosley TA, Willimanson JR FASEB, 2001; 15: 1419- 1421

Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxinitrite

Kuhn DM, Geddes TJ.

Brain Research 2002; 933: 85-89.

NAD+ dependent repair of damaged DNA by human cell extracts

Satoh MS, Pirier GG, Lindahl T.

Biol. Chem. 1993; 268; 8: 5480-5487.

Stability, Bioavailablity and Safety of NADH

Stable, ingestable and absorbable NADH and NADPH therapeutic compositions

Birkmayer JGD.

United States Patent No. 5.332.727, 1994.

Stable, ingestable and absorbable NADH and NADPH therapeutic compositions

Birkmayer JGD.

European Patent EP 0 697859, 1995.

Investigational New drug Application Birmadil™ Tablets 5mg containing reduced ß-nicotinamide adeninie dinucleotide for Treatment of Dementia of the Alzheimer’s Type

Birkmayer Pharmaceuticals

IND Number 49,766 1996.

Bioavailability of reduced nicotinamide-adenine-dinucleotide (NADH) in the central nervous system of the anaethesized rat measured by laser-induced fluorescence spectroscopy

Rex A, Hentschke MP, Fink H

Pharmacol. Toxicol. 2002; 90: 220-228.

On the Safety of Reduced Nicotinamide Adenine Nucleotide (NADH)

Birkmayer JGD, Nadlinger K, Hallström S.

Journal Environmental Pathology, Toxicology and Oncology 2004; 23: 179-194.

Applications and Beneficial Effects of NADH

Parkinson’s Disease

Stimulation of the endogenous L-dopa biosynthesis – a new principle for the therapy of Parkinson’s disease: the clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH)

Birkmayer JGD, Birkmayer W.

Acta Neurol Scan. 1989; 126:183-187.


The reduced nicotinamide adenine dinucleotide (NADH) as biological antidepressive agent. Experience with 205 patients

Birkmayer JGD, Birkmayer W

New trends in Clinical Neuropharmacology 1991; 5: 75-86.

Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats

Rex A, Schickert R, Fink H

Pharmacology, Biochemistry and Behaviour 2004; 77: 303-307.

Chronic Fatigue

The therapeutic effect of NADH in patients with Chronic Fatigue Syndrome

Forsyth L, Preuss. H, Carneiro ML, Chiazze R, Birkmayer GD, Bellanti J Ann. Allergy Asthma and Immunol., 199.9; 82: 185-191.

Functional Herbal Medicines & Dietary Supplements

Mertens G

Nicholas Hall & Company, 2000; S.17-23.

NADH improves symptoms of patients with chronic fatigue syndrome

Birkmayer JGD

The Original Internist; 1999; 6: 6-8.

Dementia of the Alzheimer Type

Treatment of Alzheimer’s Disease with stabilized oral Nicotinamide Adenine Dinucleotide: A randomized, double-blind study

Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G

Drugs exptl. Clin.Res. 2004; 30: 327-337.

ENADA/NADH improves cognitive impairment of Alzheimer patients

Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G, Martinic-Popovic,M. Puretic B., Birkmayer JGD

J. Tumor Marker Oncology 2003; 18:43-49.

Improvement of Verbal Fluency in Alzheimer’s Disease After NADH Treatment

Demarin V, Storga-Tomic D, Bosnar-Puretic M, Martinic-Popovic I, Birkmayer J

Proceedings 7th Congress European Society for Clinical Neuropharmacology ed: Medimond 2004; 41-45.


NADH in Cancer Prevention and Therapy” in Phytopharmaceuticals in Cancer Chemoprevention

Birkmayer JGD, Zhang JR, ed. Bagchi D, Preuss H CRC Press 2005; chapter 33, 541- 554.

Physical and Mental Performance

ENADAlert® improves physical and mental performance in highly conditioned athletes

Birkmayer GD, Nadlinger K.

J. Tum. Marker Oncol. 2003; 18: 51-55.

Extracellular metabolization of NADH by blood cells correlated with intracellular ATP levels

Nadlinger K, Westerthaler W, Storga-Tomic D, Birkmayer JGD

Biophys. Biochim Acta 2002; 1573: 177-182.

Jet Lag and Sleep Deprivation

Assesssing the Efficacy of Pharmaceuticals and Nutraceuticals as Countermeasures for Jet Lag

Virre ES, Kay GG

Abstr. Commun. 7th Conference Int. Society Travel Medicine 2001; FC06.03.

Effectiveness of NADH in Alleviating Effects of Sleep Deprivation in Healthy Middle-Aged Adults

Moline ML.

Study Abstract Cornell University, Sleep Wake Disorder Center December 2001.

Stabilized NADH (ENADA) as Counter-Measure Jet Lag and Sleep Deprivation

Kay GG, Virre ES, Moline M

J. Tumor Marker Oncol. 2001; 16 : 124-125.

NAD+ and NADH in brain functions, brain diseases and brain aging

Ying W.

Frontiers in Bioscience 2007; 12:1863 – 88.

NAD+ and NADH in cellular functions and cell death

Weihai Ying

Frontiers in Bioscience 2006; 11, 3129 – 3148.


Coenzym-1 (N.A.D.H.) verbessert die Symptome des klimakterischen Syndroms

JGD Birkmayer

Geburtsh Frauenheilk 2006; 67


Coenzym 1 (N.A.D.H.): A Proven Anti-Aging Substance

Birkmayer JGD

Abstr.Comm. 1st European Congress on Anti-Aging Medicine Oct. 18-21, 2006 Vienna, Austria

Method of prolonging the Life-span of Living Cells using NADH, NADPH and ADP-Ribose

Birkmayer JGD, Nadlinger K, Hallstöm S, Westerthaler W

US-Patent Pub.No. US 2004 / 0126751

Cosmetic and Dermatological Applications

NADH and NADPH therapeutic Agents for nasal, sublingual, rectal and dermal administration

Birkmayer JGD

United States Patent Nr. 5,952.312 1999.

Ointment Preparation containing NADH in Teleangiectasis

Augustin M, Zschocke I

Final Biometric Report, Universitäts Hautklinik, Freiburg, Germany Okt. 2000.

ENACHI Skin Serum – An innovative unique cosmetic product based on ENADA™- NADH

Birkmayer JGD

Nutraceuticals Now 2005; 44-45.

NADH monographies

NADH – The energizing Coenzyme

Birkmayer George D.

Keats Good Health, Keats Publishing, Inc. 1998.

NADH – the biological hydrogen – the secret of our life energy

Birkmayer George

Basic Health Publications Inc. USA, 2009

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