Publications
Publications
Effects of NADH
Birkmayer, JG: NADH (coenzyme 1) – and its anti-ageing effects.
Nutrition Press – Fachzeitschrift für Mikronährstoffe, 9: 42-44 (2016). read articleNADH-supplementation decreased pinacidil-primed I K(ATP) in ventricular cardiomyocytes by increasing intracellular ATP
Pelzmann B, Hallström S, Schaffer P, Lang P, Nadlinger K, Birkmayer GD, Vrecko C, Reibnegger G and Koidl B. Brit. J. Pharm. 2003 139, 749-754.The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) repairs DNA damage of PC12 cells induced by doxorubicin
Zhang JR, Vrecko K, Nadlinger K, Storga D, Birkmayer GD, Reibnegger G
J. Tumor Marker Oncol. 1998; 13, 5-17.
X-ray induced LO2 cells damage rescued by new antioxidant NADH
Fa-Quan L, Zhang JR.
World J. Gastorenterol. 2003, 9(8): 1781-1785.
The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) rescues PC 12 cells from Apoptosis
Zhang JR, Vrecko K, Nadlinger K. Storga D. Birkmayer GD, Reibnegger G
J. Tumor Marker Oncol. 1998; 13(3): 11-24.
The Cytoprotection of Nicotinamide Adenine Dinucleotide (NADH) by the Mitochondrial Regulation Mechanism
Meng Xu, Hang JR, Hui SSC
J. Tumor Marker Oncol. 1998; 17: 167 – 174.
The reduced coenzyme Nicotinamide Adenine Dinucleotide (NADH) prevent hepatic cells from Apoptosis
Meng Xu, Jiren Zhang
Int. Journal of Modern Cancer Therapy 2000: 3, 38 – 41.
The antioxidative capacity of ENADA®-NADH in humans
Reibnegger G, Greilberger J, Juergens G. and Oettl K.
J. Tumor Marker Oncol. 2003; 18, 37-41.
Oral NADH effects blood pressure, lipid peroxidation and lipid profile in spontaneously hypertensive rats
Busheri N, Taylor J, Lieberman S, Mirdamadi-Zonosi N, Birkmayer G, Preuss HG
Geriat. Nephrol. Urol. 1998; 18(2) 95-100.
Influence of reduced Nicotinamide Adenine Dinucleotide (NADH) on the production of Interleukin-6 by peripheral human blood leucocytes
Nadlinger K, Birkmayer J, Gebauer F, Kunze R
Neuroimmunomodulation, 2002; 9: 203-208.
NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaechromocytoma cells
Vrecko K, Storga D, Birkmayer GD, Möller R, Tarfeit E, Horejsi R, Reibnegger G
Biochimica et Biophysica Acta 1997; 1361: 59-65.
Effects of acute and chronic NADH Administration on Peripheral and Central Norepinenphrine and Dopamine Synthesis in the Rat
Gardier AM Birkmayer Institute for Parkinson Therapy, Internal Lab Report No. 94070401.NADH: Sensor of blood flow in brain, muscle and other tissues
Ido Y., Chang K., Woosley TA, Willimanson JR FASEB, 2001; 15: 1419- 1421Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxinitrite
Kuhn DM, Geddes TJ.
Brain Research 2002; 933: 85-89.
NAD+ dependent repair of damaged DNA by human cell extracts
Satoh MS, Pirier GG, Lindahl T.
Biol. Chem. 1993; 268; 8: 5480-5487.
Stability, Bioavailablity and Safety of NADH
Stable, ingestable and absorbable NADH and NADPH therapeutic compositions
Birkmayer JGD.
United States Patent No. 5.332.727, 1994.
Stable, ingestable and absorbable NADH and NADPH therapeutic compositions
Birkmayer JGD.
European Patent EP 0 697859, 1995.
Investigational New drug Application Birmadil™ Tablets 5mg containing reduced ß-nicotinamide adeninie dinucleotide for Treatment of Dementia of the Alzheimer’s Type
Birkmayer Pharmaceuticals
IND Number 49,766 1996.
Bioavailability of reduced nicotinamide-adenine-dinucleotide (NADH) in the central nervous system of the anaethesized rat measured by laser-induced fluorescence spectroscopy
Rex A, Hentschke MP, Fink H
Pharmacol. Toxicol. 2002; 90: 220-228.
On the Safety of Reduced Nicotinamide Adenine Nucleotide (NADH)
Birkmayer JGD, Nadlinger K, Hallström S.
Journal Environmental Pathology, Toxicology and Oncology 2004; 23: 179-194.
Safety of stabilized, orally absorbable, reduced nicotinamide adenine dinucleotide (NADH): A 26-week oral tablet administration of ENADA®/NADH for chronic toxicity study in rats
Birkmayer JGD, Nadlinger K.
Drugs experimental clinical Research 2002; 28: 185-182.
Applications and Beneficial Effects of NADH
Parkinson’s Disease
Nicotinamide adenine dinucleotide (NADH) – a new therapeutic approach to Parkinson’s disease: Comparison of oral and parenteral application
Birkmayer JGD, Vrecko C, Volc D, Birkmayer W
Acta Neurol Scand. 1993; 87: 32-35.
Stimulation of the endogenous L-dopa biosynthesis – a new principle for the therapy of Parkinson’s disease: the clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH)
Birkmayer JGD, Birkmayer W.
Acta Neurol Scan. 1989; 126:183-187.
Stimulation of dopamine biosynthesis in culture PC12 pheochromocytoma cells by the coenzyme nicotinamide adenine dinucleotide (NADH)
Vrecko K, Birkmayer JGD, Krainz J.
J.Neural.Transm. 1993; 5: 147-156.
Depression
The reduced nicotinamide adenine dinucleotide (NADH) as biological antidepressive agent. Experience with 205 patients
Birkmayer JGD, Birkmayer W
New trends in Clinical Neuropharmacology 1991; 5: 75-86.
Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats
Rex A, Schickert R, Fink H
Pharmacology, Biochemistry and Behaviour 2004; 77: 303-307.
Chronic Fatigue
The therapeutic effect of NADH in patients with Chronic Fatigue Syndrome
Forsyth L, Preuss. H, Carneiro ML, Chiazze R, Birkmayer GD, Bellanti J Ann. Allergy Asthma and Immunol., 199.9; 82: 185-191.Functional Herbal Medicines & Dietary Supplements
Mertens G
Nicholas Hall & Company, 2000; S.17-23.
NADH improves symptoms of patients with chronic fatigue syndrome
Birkmayer JGD
The Original Internist; 1999; 6: 6-8.
Dementia of the Alzheimer Type
Treatment of Alzheimer’s Disease with stabilized oral Nicotinamide Adenine Dinucleotide: A randomized, double-blind study
Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G
Drugs exptl. Clin.Res. 2004; 30: 327-337.
ENADA/NADH improves cognitive impairment of Alzheimer patients
Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G, Martinic-Popovic,M. Puretic B., Birkmayer JGD
J. Tumor Marker Oncology 2003; 18:43-49.
Improvement of Verbal Fluency in Alzheimer’s Disease After NADH Treatment
Demarin V, Storga-Tomic D, Bosnar-Puretic M, Martinic-Popovic I, Birkmayer J
Proceedings 7th Congress European Society for Clinical Neuropharmacology ed: Medimond 2004; 41-45.
Cancer
NADH in Cancer Prevention and Therapy” in Phytopharmaceuticals in Cancer Chemoprevention
Birkmayer JGD, Zhang JR, ed. Bagchi D, Preuss H CRC Press 2005; chapter 33, 541- 554.Physical and Mental Performance
ENADAlert® improves physical and mental performance in highly conditioned athletes
Birkmayer GD, Nadlinger K.
J. Tum. Marker Oncol. 2003; 18: 51-55.
Extracellular metabolization of NADH by blood cells correlated with intracellular ATP levels
Nadlinger K, Westerthaler W, Storga-Tomic D, Birkmayer JGD
Biophys. Biochim Acta 2002; 1573: 177-182.
Jet Lag and Sleep Deprivation
Assesssing the Efficacy of Pharmaceuticals and Nutraceuticals as Countermeasures for Jet Lag
Virre ES, Kay GG
Abstr. Commun. 7th Conference Int. Society Travel Medicine 2001; FC06.03.
Effectiveness of NADH in Alleviating Effects of Sleep Deprivation in Healthy Middle-Aged Adults
Moline ML.
Study Abstract Cornell University, Sleep Wake Disorder Center December 2001.
Stabilized NADH (ENADA) as Counter-Measure Jet Lag and Sleep Deprivation
Kay GG, Virre ES, Moline M
J. Tumor Marker Oncol. 2001; 16 : 124-125.
NAD+ and NADH in brain functions, brain diseases and brain aging
Ying W.
Frontiers in Bioscience 2007; 12:1863 – 88.
NAD+ and NADH in cellular functions and cell death
Weihai Ying
Frontiers in Bioscience 2006; 11, 3129 – 3148.
Menopause
Coenzym-1 (N.A.D.H.) verbessert die Symptome des klimakterischen Syndroms
JGD Birkmayer
Geburtsh Frauenheilk 2006; 67
Anti-Aging
Coenzym 1 (N.A.D.H.): A Proven Anti-Aging Substance
Birkmayer JGD
Abstr.Comm. 1st European Congress on Anti-Aging Medicine Oct. 18-21, 2006 Vienna, Austria
Method of prolonging the Life-span of Living Cells using NADH, NADPH and ADP-Ribose
Birkmayer JGD, Nadlinger K, Hallstöm S, Westerthaler W
US-Patent Pub.No. US 2004 / 0126751
Cosmetic and Dermatological Applications
NADH and NADPH therapeutic Agents for nasal, sublingual, rectal and dermal administration
Birkmayer JGD
United States Patent Nr. 5,952.312 1999.
Ointment Preparation containing NADH in Teleangiectasis
Augustin M, Zschocke I
Final Biometric Report, Universitäts Hautklinik, Freiburg, Germany Okt. 2000.
ENACHI Skin Serum – An innovative unique cosmetic product based on ENADA™- NADH
Birkmayer JGD
Nutraceuticals Now 2005; 44-45.
NADH monographies
NADH – The energizing Coenzyme
Birkmayer George D.
Keats Good Health, Keats Publishing, Inc. 1998.
NADH – the biological hydrogen – the secret of our life energy
Birkmayer George
Basic Health Publications Inc. USA, 2009